Structural Modifications of Hadacidin and Their Effects on the Activity of Adenylosuccinate Synthetase.
نویسنده
چکیده
Previous work from this laboratory demonstrated that hadacidin (N-formylhydroxyaminoacetate) inhibited the biosynthesis & luwo of adenylic acid in Ehrlich ascites tumor and rat liver cells. This effect, which was shown to be due to the inhibition of adenylosuccinate synthetase (IMP : L-aspartate ligase (1))) was competitively reversed by L-aspartate (2, 3). The structural similarity between aspartic acid and its metabolic analogue, hadacidin, is shown in Formula 1.
منابع مشابه
The Mechanism of Action of Hadacidine
Data obtained from experiments in vivo and in vitro with various isotopic precursors have demonstrated that the new compound, N-formyl hydroxyaminoacetate (hadacidin), inhibited the biosynthesis de novo of adenylic and deoxyadenylic acids (1). Preliminary observations have further indicated that the site of action was in the conversion of inosinic acid to adenylosuccinic acid. Adenylosuccinate ...
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عنوان ژورنال:
- The Journal of biological chemistry
دوره 238 شماره
صفحات -
تاریخ انتشار 1963